A Study on Standard Tablet Formulation based on Fluidized-bed Granulation.
نویسندگان
چکیده
منابع مشابه
Granulation Time in Fluidized Bed Granulators
Size enlargement of fine powders by wet granulation involves mixing of fine particles with a binder liquid to form larger wet granules and drying them by evaporation of the binder liquid to form larger dry granules. Identification of the time for completion of granulation process is critical as further mixing of dry granules is providing extra energy for their attrition. In a batch fluidized be...
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Here, we statistically identified the critical factor of the granulation rate during the fluidized bed granulation process. Lactose was selected as the excipient and was granulated with several binders, including hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and polyvinylpyrrolidone. The viscosity, density, and surface tension of the binder solution, contact angle, and the work done ...
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Online Optimization of a Top-spray Fluidized Bed Granulation Process Based on a Three-stage Population Balance Model
A multi-scale three-stage population balance model (TSPBM) was developed in combination with the multivariate projection models to obtain the unknown kernel constants in population balance model (PBM), considering the batch and multi-stage characteristics of the top-spray fluidized bed granulation process. Partial least square (PLS) regression is adopted as the particle-scale modeling method in...
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This paper is concerned with adaptive stabilization of open loop unstable fluidized bed spray granulation with internal product classification by means of nonlinear feedback control. Since the process model is represented by a nonlinear partial integro-differential equation, direct stabilization of the particle size distribution in a Lp or L∞ norm is difficult. To overcome this problem a stabil...
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ژورنال
عنوان ژورنال: Journal of the Society of Powder Technology, Japan
سال: 1996
ISSN: 0386-6157,1883-7239
DOI: 10.4164/sptj.33.481